Chlamydia as the cause of ovarian cancer
There is growing evidence that connects chlamydial infection to ovarian carcinoma. Chlamydia is known to activate prosurvival signals that protects the infected cells from apoptotic cell death. In this project we aim to consolidate Chlamydia infection as a cause of ovarian cancer in tumor models of infection. These are based on our knowledge on the signaling pathways that are activated during infection and are known to predispose tissue towards malignancy. Our study will help to understand the molecular mechanisms that direct infection signaling to cancer.