Deutsch
    Chair of Microbiology

    PD Dr. Vera Kozjak-Pavlovic

    Contact information:  

    Tel.: +49 (0)931-31 88061
    E-mail: vera.kozjak@uni-wuerzburg.de
    Room: C226

    Team

    Elke Maier
    Phone: 31-84500
    E-mail: emaier@biozentrum.uni-wuerzburg.de
    Room: C237

    Motaharehsadat Heydarian
    Phone: 31-86899
    E-mail: motaharehsadat.heydarian@uni-wuerzburg.de
    Room: C237

    Tao Yang
    Phone: 31-84243
    E-mail: tao.yang@uni-wuerzburg.de
    Room: C237

    Curriculum vitae

    Academic Career

    1995-2000:  Undergraduate studies at the Department of Molecular Biology and 
                           Physiology, Faculty of Biology, University of Belgrade, Serbia;
                           Applied Biochemistry Major

    1999-2001:  Research in the group of Dr. Branka Vasiljevic, Laboratory for Molecular
                           Genetics of Actinomycetes, Institute for Molecular Genetics and Genetic
                           Engineering, Belgrade, Serbia

    2001-2004:  Ph.D. work in the group of Prof. Dr. Nikolaus Pfanner at the
                           Institute for Biochemistry and Molecular Biology,
                           Albert-Ludwigs-University, Freiburg im Breisgau, Germany

    2005-2007:  Postdoctoral fellow in the group of Prof. Dr. Thomas Rudel,
                           Max Planck Institute for Infection Biology, Berlin, Germany;
                           Alexander von Humboldt research fellowship

    2008-2009:  Maternity leave

    since 2009  Group leader at the Biocenter, Department of Microbiology,
                          Julius-Maximilians-University Würzburg, Germany

    2013:            Habilitation and venia legendi in microbiology, at the Fakulty of Biology,
                          Julius-Maximilians-University Würzburg, Germany

    2015:            Marcella Boveri Prize

    Publications
    • Chowdhury SR, Reimer A, Sharan M, Kozjak-Pavlovic V, Eulalio A, Prusty BK, Fraunholz M, Karunakaran K, Rudel T. (2017) J Cell Biol. 216(4):1071-1089. PubMed

    • Chiusolo V, Jacquemin G, Yonca Bassoy E, Vinet L, Liguori L, Walch M, Kozjak-Pavlovic V, Martinvalet D. (2017) Granzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis. Cell Death Differ. 24(4):747-758. PubMed

    • Reimer A, Seufert F, Weiwad M, Ebert J, Bzdyl NM, Kahler CM, Sarkar-Tyson M, Holzgrabe U, Rudel T, Kozjak-Pavlovic V. (2016) Inhibitors of macrophage infectivity potentiator-like PPIases affect neisserial and chlamydial pathogenicity. Int J Antimicrob Agents. 48(4):401-8. PubMed

    • Cheng C, Othman EM, Reimer A, Grüne M, Kozjak-Pavlovic V, Stopper H, Hentschel U, Abdelmohsen UR. (2016) Ageloline A, new antioxidant and antichlamydial quinolone from the marine sponge-derived bacterium Streptomyces sp. SBT345. Tetrahedron Lett. doi:10.1016/j.tetlet.2016.05.041

    • Kozjak-Pavlovic V. (2016) The MICOS complex of human mitochondria. Cell Tissue Res.  367(1):83-93. PubMed

    • Gao S, Nagpal J, Schneider MW, Kozjak-Pavlovic V, Nagel G, Gottschalk A. (2015) Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp. Nat Commun. 6:8046. PubMed

    • Reimer A, Blohm A, Quack T, Grevelding CG, Kozjak-Pavlovic V, Rudel T, Hentschel U, Abdelmohsen UR. (2015) Inhibitory activities of the marine streptomycete-derived compound SF2446A2 against Chlamydia trachomatis and Schistosoma mansoni. J Antibiot (Tokyo). 68(11):674-9. PubMed

    • Frank DO, Dengjel J, Wilfling F, Kozjak-Pavlovic V, Häcker G, Weber A. (2015) The pro-apoptotic BH3-only protein Bim interacts with components of the translocase of the outer mitochondrial membrane (TOM). PLoS One. 10(4):e0123341. PubMed

    • Ott C, Dorsch E, Fraunholz M, Straub S, Kozjak-Pavlovic V. (2015) Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. PLoS One. 10(3):e0120213. PubMed

    • Faulstich M, Hagen F, Avota E, Kozjak-Pavlovic V, Winkler AC, Xian Y, Schneider-Schaulies S, Rudel T. (2015) Neutral sphingomyelinase 2 is a key factor for PorB-dependent invasion of Neisseria gonorrhoeae. Cell Microbiol. 17(2):241-53. PubMed

    • Ioakeimidis F, Ott C, Kozjak-Pavlovic V, Violitzi F, Rinotas V, Makrinou E, Eliopoulos E, Fasseas C, Kollias G, Douni E. (2014) A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice. PLoS One. 9(8):e104237. PubMed

    • Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J. (2014) Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol. 204(7):1083-6. PubMed

    • Kozjak-Pavlovic V, Prell F, Thiede B, Götz M, Wosiek D, Ott C, Rudel T. (2013) C1orf163/RESA1 Is a Novel Mitochondrial Intermembrane Space Protein Connected to Respiratory Chain Assembly. J Mol Biol. 426(4):908-20. Pub Med

    • Kato H, Lu Q, Rapaport D, Kozjak-Pavlovic V. (2013) Tom70 is essential for PINK1 import into mitochondria. PLoS One. 8(3):e58435. PubMed

    • Ott C, Utech M, Goetz M, Rudel T, Kozjak-Pavlovic V. (2013) The requirements for the import of neisserial Omp85 into the outer membrane of human mitochondria. Biosci Rep. 33(2):e00028.  PubMed

    • Ott C, Ross K, Straub S, Thiede B, Götz M, Goosmann C, Krischke M, Mueller MJ, Krohne G, Rudel T, Kozjak-Pavlovic V. (2012) Sam50 functions in mitochondrial intermembrane space bridging and biogenesis of respiratory complexes. Mol Cell Biol. 32(6):1173-88. PubMed

    • Kozjak-Pavlovic V, Ott C, Götz M, Rudel T. (2011) Neisserial Omp85 protein is selectively recognized and assembled into functional complexes in the outer membrane of human mitochondria. J Biol Chem. 286(30):27019-26. PubMed

    • Rudel T, Kepp O, Kozjak-Pavlovic V (2010) Interactions between bacterial pathogens and mitochondrial cell death pathways. Nat Rev Microbiol. 8(10):693-705. PubMed

    • Niu H, Kozjak-Pavlovic V, Rudel T, Rikihisa Y. (2010) Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction. PLoS Pathog. 6(2):e1000774. PubMed

    • Kozjak-Pavlovic V, Ross K, Götz M, Goosmann C, Rudel T. (2010) A tag at the carboxy terminus prevents membrane integration of VDAC1 in mammalian mitochondria. J Mol Biol. 397(1):219-32. PubMed

    • Kozjak-Pavlovic V, Dian-Lothrop EA, Meinecke M, Kepp O, Ross K, Rajalingam K, Harsman A, Hauf E, Brinkmann V, Günther D, Herrmann I, Hurwitz R, Rassow J, Wagner R, Rudel T. (2009) Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis. PLoS Pathog5(10):e1000629. PubMed

    • Ross K, Rudel T, Kozjak-Pavlovic V (2009) Tom-independent complex formation of Bax and Bak in mammalian mitochondria during TNFa-induced apoptosis. Cell Death Diff  16(5):697-707. PubMed

    • Kozjak-Pavlovic V, Ross K, Rudel T (2008) Import of bacterial pathogenicity factors into mitochondria. Curr Opin Microbiol 11:9-14. PubMed

    • Kozjak-Pavlovic V, Ross K, Benlasfer N, Kimmig S, Karlas A, Rudel T (2007) Conserved roles of Sam50 and metaxins in VDAC biogenesis. EMBO Rep 8:576-582. PubMed

    • Milenkovic D, Kozjak V, Wiedemann N, Lohaus C, Meyer HE, Guiard B, Pfanner N, Meisinger C (2004)
      Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability. J Biol Chem 279:22781-22785. PubMed

    • Kozjak V, Wiedemann N, Milenkovic D, Lohaus C, Meyer HE, Guiard B, Meisinger C, Pfanner N (2003)
      An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane. J Biol Chem  278:48520-48523. PubMed

    • Wiedemann N, Kozjak V, Chacinska A, Schönfisch B, Rospert S, Ryan MT, Pfanner N, Meisinger C (2003) Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature 424:565-571. PubMed
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    Phone: +49 931 31-0
    Fax: +49 931 31-82600

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