English
    Lehrstuhl für Mikrobiologie

    Acid Sphingomyelinase-Dependent Virulence of Staphylococcus aureus Toxins

    The acid sphingomyelinase/ceramide system is an important mediator of bacterial infections. Recently, acid sphingomyelinase and ceramide were demonstrated to mediate the disruption of tight junctions of endothelial cells in vitro and in vivo upon infection with Staphylococcus aureus.

    In this project we therefore aim identify bacterial toxins that activate the acid sphingomyelinase/ceramide system. Molecular mechanisms by which these toxins stimulate acid sphingomyelinase and trigger the release of ceramide are characterized.

    Funding is provided by Deutsche Forschungsgemeinschaft within FOR2123 "Sphingolipids in infection control".

    Kontakt
    Biozentrum
    Universität Würzburg
    Theodor-Boveri-Weg
    97074 Würzburg

    Tel. +49 931 31-84400
    Fax: +49 931 31-84402

    Suche Ansprechpartner
    Hubland Süd Hubland Nord Campus Dallenberg Fabrikschleichach Humangenetik Campus Medizin