English
    Lehrstuhl für Mikrobiologie

    Prof. Dr. Thomas Rudel

    Kontakt:  

    Tel.: +49 (0)931-31 84401
    E-mail: thomas.rudel@biozentrum.uni-wuerzburg.de
    Raum: C202

    Sprechstunde:

    nach Vereinbarung

    Forschungsprojekte:

    Curriculum vitae

    Academic Career

    • 1983-1989:          Studies of Biology, University of Tübingen

    • 1989-1994:          PhD in Microbiology, Max Planck Institute for Biology, Tübingen

    • 1994-1995:          Staff scientist, Max Planck Institute for Biology, Tübingen

    • 1995-1996:          Postdoctoral fellow, Scripps Research Institute, San Diego, USA

    • 1997-2008:          Group leader, Max Planck Institute for Infection Biology, Berlin

    • 2001:                    Habilitation (Microbiology), Free University Berlin

    • 2003:                    Associate Professor, Max Planck Institute for Infection Biology, Berlin

    • since 2008:         Chair Professor, Chair of Microbiology, University of Würzburg
    Publikationen

       

    • Eisenreich W, Rudel T, Heesemann J, Goebel W. To Eat and to Be Eaten: Mutual Metabolic Adaptations of Immune Cells and Intracellular Bacterial Pathogens upon Infection. Front Cell Infect Microbiol. 2017 Jul 13;7:316. doi: 10.3389/fcimb.2017.00316.

    • Chowdhury SR, Rudel T. Chlamydia and mitochondria - an unfragmented relationship. Microb Cell. 2017 Jun 14;4(7):233-235. doi: 10.15698/mic2017.07.582.

    • Tanwer P, Bauer S, Heinrichs E, Panda G, Saluja D, Rudel T, Beier D. Post-transcriptional regulation of target genes by the sRNA FnrS in Neisseria gonorrhoeae. Microbiology. 2017 Jul;163(7):1081-1092. doi: 10.1099/mic.0.000484.

    • Fischer A, Harrison KS, Ramirez Y, Auer D, Chowdhury SR, Prusty BK, Sauer F, Dimond Z, Kisker C, Scott Hefty P, Rudel T. Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense. Elife. 2017 Mar 28;6. pii: e21465.doi: 10.7554/eLife.21465.

    • Gupta N, Noel R, Goudet A, Hinsinger K, Michau A, Pons V, Abdelkafi H, Secher T, Shima A, Shtanko O, Sakurai Y, Cojean S, Pomel S, Lievin-Le Moal V, Leignel V, Herweg JA, Fischer A, Johannes L, Harrison K, Beard PM, Clayette P, Le Grand R, Rayner JO, Rudel T, Vacus J, Loiseau PM, Davey RA, Oswald E, Cintrat JC, Barbier J, Gillet D. Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales. Chem Biol Interact. 2017 Apr 1;267:96-103 doi: 10.1016/j.cbi.2016.10.005 PMID: 27712998

    • Mehlitz A, Eylert E, Huber C, Lindner B, Vollmuth N, Karunakaran K, Goebel W, Eisenreich W, Rudel T. Metabolic adaptation of Chlamydia trachomatis to mammalian host cells. Mol Microbiol. 2017 Mar 103(6):1004-1019. doi: 10.1111/mmi.13603 PMID: 27997721

    • Chowdhury SR, Reimer A, Sharan M, Kozjak-Pavlovic V, Eulalio A, Prusty BK, Fraunholz M, Karunakaran K, Rudel T. Chlamydia preserves the mitochondrial network necessary for replication via microRNA-dependent inhibition of fission. J Cell Biol. 2017 Mar 22. pii: jcb.201608063. doi: 10.1083/jcb.201608063 PMID: 28330939

    • Reimer A, Seufert F, Weiwad M, Ebert J, Bzdyl NM, Kahler CM, Sarkar-Tyson M, Holzgrabe U, Rudel T, Kozjak-Pavlovic V. Inhibitors of macrophage infectivity potentiator-like PPIases affect neisserial and chlamydial pathogenicity. Int J Antimicrob Agents. 2016 Oct 48(4):401-8. doi: 10.1016/j.ijantimicag.2016.06.020 PMID: 27516227

    • Blättner S, Das S, Paprotka K, Eilers U, Krischke M, Kretschmer D, Remmele CW, Dittrich M, Müller T, Schuelein-Voelk C, Hertlein T, Mueller MJ, Huettel B, Reinhardt R, Ohlsen K, Rudel T, Fraunholz MJ. Staphylococcus aureus Exploits a Non-ribosomal Cyclic Dipeptide to Modulate Survival within Epithelial Cells and Phagocytes. PLoS Pathog. 2016 Sep 15;12(9):e1005857 doi: 10.1371/journal.ppat.1005857 "PMID: 27632173; PMCID: PMC5025175"

    • Fischer A, Rudel T. Subversion of Cell-Autonomous Host Defense by Chlamydia Infection. Curr Top Microbiol Immunol. 2016 May 13. PMID: 27169422

    • Das S, Lindemann C, Young BC, Muller J, Österreich B, Ternette N, Winkler AC, Paprotka K, Reinhardt R, Förstner KU, Allen E, Flaxman A, Yamaguchi Y, Rollier CS, van Diemen P, Blättner S, Remmele CW, Selle M, Dittrich M, Müller T, Vogel J, Ohlsen K, Crook DW, Massey R, Wilson DJ, Rudel T, Wyllie DH, Fraunholz MJ. Natural mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation. Proc Natl Acad Sci U S A. 2016 May 31;113(22):E3101-10 doi: 10.1073/pnas.1520255113 "PMID: 27185949; PMCID: PMC4896717"

    • Herweg JA, Rudel T. Interaction of Chlamydiae with human macrophages. FEBS J. 2016 Feb 283(4):608-18. doi: 10.1111/febs.13609 PMID: 26613554

    • Herweg JA, Pons V, Becher D, Hecker M, Krohne G, Barbier J, Berger H, Rudel T, Mehlitz A. Proteomic analysis of the Simkania-containing vacuole: the central role of retrograde transport. Mol Microbiol. 2016 Jan 99(1):151-71. doi: 10.1111/mmi.13222 PMID: 26374382

    • Siegl C, Rudel T. Modulation of p53 during bacterial infections. Nat Rev Microbiol. 2015 Dec 13(12):741-8. doi: 10.1038/nrmicro3537 PMID: 26548915

    • Rudel TK, Paul B, White D, Rao IM, Van Der Hoek R, Castro A, Boval M, Lerner A, Schneider L, Peters M. LivestockPlus: Forages, sustainable intensification, and food security in the tropics. Ambio. 2015 Nov 44(7):685-93. doi: 10.1007/s13280-015-0676-2 "PMID: 26121947; PMCID: PMC4591233"

    • Reimer A, Blohm A, Quack T, Grevelding CG, Kozjak-Pavlovic V, Rudel T, Hentschel U, Abdelmohsen UR. Inhibitory activities of the marine streptomycete-derived compound SF2446A2 against Chlamydia trachomatis and Schistosoma mansoni. J Antibiot (Tokyo). 2015 Nov 68(11):674-9. doi: 10.1038/ja.2015.54 PMID: 25990954

    • Karunakaran K, Subbarayal P, Vollmuth N, Rudel T. Chlamydia-infected cells shed Gp96 to prevent chlamydial re-infection. Mol Microbiol. 2015 Nov 98(4):694-711. doi: 10.1111/mmi.13151 PMID: 26235316

    • Eisenreich W, Heesemann J, Rudel T, Goebel W. Metabolic Adaptations of Intracellullar Bacterial Pathogens and their Mammalian Host Cells during Infection (Pathometabolism). Microbiol Spectr. 2015 Jun 3(3). doi: 10.1128/microbiolspec.MBP-0002-2014 PMID: 26185075

    • Herweg JA, Hansmeier N, Otto A, Geffken AC, Subbarayal P, Prusty BK, Becher D, Hensel M, Schaible UE, Rudel T, Hilbi H. Purification and proteomics of pathogen-modified vacuoles and membranes. Front Cell Infect Microbiol. 2015 Jun 2;5:48 doi: 10.3389/fcimb.2015.00048 "PMID: 26082896; PMCID: PMC4451638"

    • Subbarayal P, Karunakaran K, Winkler AC, Rother M, Gonzalez E, Meyer TF, Rudel T. EphrinA2 receptor (EphA2) is an invasion and intracellular signaling receptor for Chlamydia trachomatis. PLoS Pathog. 2015 Apr 23;11(4):e1004846 doi: 10.1371/journal.ppat.1004846 "PMID: 25906164; PMCID: PMC4408118"

    • Abdelmohsen UR, Cheng C, Reimer A, Kozjak-Pavlovic V, Ibrahim AK, Rudel T, Hentschel U, Edrada-Ebel R, Ahmed SA. Antichlamydial sterol from the Red Sea sponge Callyspongia aff. implexa. Planta Med. 2015 Mar 81(5):382-7. doi: 10.1055/s-0035-1545721 PMID: 25782033

    • Faulstich M, Hagen F, Avota E, Kozjak-Pavlovic V, Winkler AC, Xian Y, Schneider-Schaulies S, Rudel T. Neutral sphingomyelinase 2 is a key factor for PorB-dependent invasion of Neisseria gonorrhoeae. Cell Microbiol. 2015 Feb 17(2):241-53. doi: 10.1111/cmi.12361 PMID: 25224994

    • Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015 Jan 22(1):58-73. doi: 10.1038/cdd.2014.137 "PMID: 25236395; PMCID: PMC4262782"

    • Prusty BK, Siegl C, Gulve N, Mori Y, Rudel T. GP96 interacts with HHV-6 during viral entry and directs it for cellular degradation. PLoS One. 2014 Dec 3;9(12):e113962 doi: 10.1371/journal.pone.0113962 "PMID: 25470779; PMCID: PMC4254946"

    • Siegl C, Prusty BK, Karunakaran K, Wischhusen J, Rudel T. Tumor suppressor p53 alters host cell metabolism to limit Chlamydia trachomatis infection. Cell Rep. 2014 Nov 6;9(3):918-29 doi: 10.1016/j.celrep.2014.10.004 PMID: 25437549

    • Volceanov L, Herbst K, Biniossek M, Schilling O, Haller D, Nölke T, Subbarayal P, Rudel T, Zieger B, Häcker G. Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion. MBio. 2014 Oct 7;5(5):e01802-14 doi: 10.1128/mBio.01802-14 "PMID: 25293760; PMCID: PMC4196233"

    • Gurumurthy RK, Chumduri C, Karlas A, Kimmig S, Gonzalez E, Machuy N, Rudel T, Meyer TF. Dynamin-mediated lipid acquisition is essential for Chlamydia trachomatis development. Mol Microbiol. 2014 Oct 94(1):186-201. doi: 10.1111/mmi.12751 PMID: 25116793

    • Mehlitz A, Karunakaran K, Herweg JA, Krohne G, van de Linde S, Rieck E, Sauer M, Rudel T. The chlamydial organism Simkania negevensis forms ER vacuole contact sites and inhibits ER-stress. Cell Microbiol. 2014 Aug 16(8):1224-43. doi: 10.1111/cmi.12278 PMID: 24528559

    • Albrecht R, Schütz M, Oberhettinger P, Faulstich M, Bermejo I, Rudel T, Diederichs K, Zeth K. Structure of BamA, an essential factor in outer membrane protein biogenesis. Acta Crystallogr D Biol Crystallogr. 2014 Jun 70(Pt 6):1779-89. doi: 10.1107/S1399004714007482 PMID: 24914988

    • Baur S, Rautenberg M, Faulstich M, Grau T, Severin Y, Unger C, Hoffmann WH, Rudel T, Autenrieth IB, Weidenmaier C. A nasal epithelial receptor for Staphylococcus aureus WTA governs adhesion to epithelial cells and modulates nasal colonization. PLoS Pathog. 2014 May 1;10(5):e1004089 doi: 10.1371/journal.ppat.1004089

    • Grosz M, Kolter J, Paprotka K, Winkler AC, Schäfer D, Chatterjee SS, Geiger T, Wolz C, Ohlsen K, Otto M, Rudel T, Sinha B, Fraunholz M. Cytoplasmic replication of Staphylococcus aureus upon phagosomal escape triggered by phenol-soluble modulin α. Cell Microbiol. 2014 Apr 16(4):451-65. doi: 10.1111/cmi.12233 "PMID: 24164701; PMCID: PMC3969633"

    • Kozjak-Pavlovic V, Prell F, Thiede B, Götz M, Wosiek D, Ott C, Rudel T. C1orf163/RESA1 is a novel mitochondrial intermembrane space protein connected to respiratory chain assembly. J Mol Biol. 2014 Feb 20;426(4):908-20 doi: 10.1016/j.jmb.2013.12.001 PMID: 24333015

    • Remmele CW, Xian Y, Albrecht M, Faulstich M, Fraunholz M, Heinrichs E, Dittrich MT, Müller T, Reinhardt R, Rudel T. Transcriptional landscape and essential genes of Neisseria gonorrhoeae. Nucleic Acids Res. "2014;42(16):10579-95 doi: 10.1093/nar/gku762 "PMID: 25143534; PMCID: PMC4176332"

    • Sibilski C, Mueller T, Kollipara L, Zahedi RP, Rapp UR, Rudel T, Baljuls A. Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase. J Biol Chem. 2013 Dec 6;288(49):35237-52 doi: 10.1074/jbc.M113.490235 "PMID: 24158441; PMCID: PMC3853273"

    • Mehlitz A, Rudel T. Modulation of host signaling and cellular responses by Chlamydia. Cell Commun Signal. 2013 Nov 22;11:90 doi: 10.1186/1478-811X-11-90 "PMID: 24267514; PMCID: PMC4222901"
    • Eisenreich W, Heesemann J, Rudel T, Goebel W. Metabolic host responses to infection by intracellular bacterial pathogens. Front Cell Infect Microbiol. 2013 Jul 9;3:24 doi: 10.3389/fcimb.2013.00024 "PMID: 23847769; PubMed Central PMCID: PMC3705551"

    • Rudel TK. The national determinants of deforestation in sub-Saharan Africa. Philos Trans R Soc Lond B Biol Sci. 2013 Jul 22;368(1625):20120405 doi: 10.1098/rstb.2012.0405 "PMID: 23878341; PMCID: PMC3720032"

    • Prusty BK, Siegl C, Hauck P, Hain J, Korhonen SJ, Hiltunen-Back E, Puolakkainen M, Rudel T. Chlamydia trachomatis infection induces replication of latent HHV-6. PLoS One. 2013 Apr 19;8(4):e61400 doi: 10.1371/journal.pone.0061400 "PMID: 23620749; PMCID: PMC3631192"

    • Ott C, Utech M, Goetz M, Rudel T, Kozjak-Pavlovic V. Requirements for the import of neisserial Omp85 into the outer membrane of human mitochondria. Biosci Rep. 2013 Mar 13;33(2):e00028 doi: 10.1042/BSR20130007 "PMID: 23368846; PMCID: PMC3596097"

    • Zeth K, Kozjak-Pavlovic V, Faulstich M, Fraunholz M, Hurwitz R, Kepp O, Rudel T. Structure and function of the PorB porin from disseminating Neisseria gonorrhoeae. Biochem J. 2013 Feb 1;449(3):631-42 doi: 10.1042/BJ20121025Erratum in: Biochem J.

    • Castro IC, Breiling A, Luetkenhaus K, Ceteci F, Hausmann S, Kress S, Lyko F, Rudel T, Rapp UR. MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma. Mol Cancer Res. 2013 Feb 11(2):161-72. doi: 10.1158/1541-7786.MCR-12-0414-T PMID: 23239811

    • Prusty BK, Krohne G, Rudel T. Reactivation of chromosomally integrated human herpesvirus-6 by telomeric circle formation. PLoS Genet. "2013;9(12):e1004033 doi: 10.1371/journal.pgen.1004033 "PMID: 24367281; PMCID: PMC3868596"

    • Faulstich M, Böttcher JP, Meyer TF, Fraunholz M, Rudel T. Pilus phase variation switches gonococcal adherence to invasion by caveolin-1-dependent host cell signaling. PLoS Pathog. "2013;9(5):e1003373 doi: 10.1371/journal.ppat.1003373 "PMID: 23717204; PMCID: PMC3662692"

    • Rajalingam K, Rudel T. Prohibiting CRAF/MAPK activation with rocaglamides. Chem Biol. 2012 Sep 21;19(9):1077-8 doi: 10.1016/j.chembiol.2012.09.004PubMed PMID: 22999872

    • Baljuls A, Beck M, Oenel A, Robubi A, Kroschewski R, Hekman M, Rudel T, Rapp UR. The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF. J Biol Chem. 2012 Jun 29;287(27):23128-40 doi: 10.1074/jbc.M112.343780 "PMID: 22605333; PMCID: PMC3391090"

    • Rudel T. To die or not to die: Shigella has an answer. Cell Host Microbe. 2012 Mar 15;11(3):219-21 doi: 10.1016/j.chom.2012.02.004 PMID: 22423960

    • Ott C, Ross K, Straub S, Thiede B, Götz M, Goosmann C, Krischke M, Mueller MJ, Krohne G, Rudel T, Kozjak-Pavlovic V. Sam50 functions in mitochondrial intermembrane space bridging and biogenesis of respiratory complexes. Mol Cell Biol. 2012 Mar 32(6):1173-88. doi: 10.1128/MCB.06388-11 "PMID: 22252321; PMCID: PMC3295012"

    • Prusty BK, Böhme L, Bergmann B, Siegl C, Krause E, Mehlitz A, Rudel T. Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection. PLoS One. "2012;7(10):e47427 doi: 10.1371/journal.pone.0047427 "PMID: 23077614; PMCID: PMC3471814"

    • Sharma M, Machuy N, Böhme L, Karunakaran K, Mäurer AP, Meyer TF, Rudel T. HIF-1alpha is involved in mediating apoptosis resistance to Chlamydia trachomatis-infected cells. Cell Microbiol. 2011 Oct 13(10):1573-85. doi: 10.1111/j.1462-5822.2011.01642.x PMID: 21824245

    • Albrecht M, Sharma CM, Dittrich MT, Müller T, Reinhardt R, Vogel J, Rudel T. The transcriptional landscape of Chlamydia pneumoniae. Genome Biol. 2011 Oct 11;12(10):R98 doi: 10.1186/gb-2011-12-10-r98 "PMID: 21989159; PMCID: PMC3333780"

    • Kozjak-Pavlovic V, Ott C, Götz M, Rudel T. Neisserial Omp85 protein is selectively recognized and assembled into functional complexes in the outer membrane of human mitochondria. J Biol Chem. 2011 Jul 29;286(30):27019-26 doi: 10.1074/jbc.M111.232249 "PMID: 21652692; PMCID: PMC3143660"

    • Cornfine S, Himmel M, Kopp P, El Azzouzi K, Wiesner C, Krüger M, Rudel T, Linder S. The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes. Mol Biol Cell. 2011 Jan 15;22(2):202-15 doi: 10.1091/mbc.E10-05-0394 "PMID: 21119006; PMCID: PMC3020916"

    • Prusty BK, Karlas A, Meyer TF, Rudel T. Genome-wide RNAi screen for viral replication in mammalian cell culture. Methods Mol Biol. "2011;721:383-95 doi: 10.1007/978-1-61779-037-9_24 PMID: 21431699

    • Karunakaran K, Mehlitz A, Rudel T. Evolutionary conservation of infection-induced cell death inhibition among Chlamydiales. PLoS One. "2011;6(7):e22528 doi: 10.1371/journal.pone.0022528 "PMID: 21799887; PMCID: PMC3142178"

    • Meyfroidt P, Rudel TK, Lambin EF. Forest transitions, trade, and the global displacement of land use. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20917-22. doi: 10.1073/pnas.1014773107 "PMID: 21078977; PMCID: PMC3000287"

    • Rudel T, Kepp O, Kozjak-Pavlovic V. Interactions between bacterial pathogens and mitochondrial cell death pathways. Nat Rev Microbiol. 2010 Oct 8(10):693-705. doi: 10.1038/nrmicro2421 PMID: 20818415

    • Sievers C, Billig G, Gottschalk K, Rudel T. Prohibitins are required for cancer cell proliferation and adhesion. PLoS One. 2010 Sep 14;5(9):e12735 doi: 10.1371/journal.pone.0012735 "PMID: 20856874; PMCID: PMC2939069"

    • Böhme L, Albrecht M, Riede O, Rudel T. Chlamydia trachomatis-infected host cells resist dsRNA-induced apoptosis. Cell Microbiol. 2010 Sep 1;12(9):1340-51 doi: 10.1111/j.1462-5822.2010.01473.x PMID: 20482554

    • Prakash H, Albrecht M, Becker D, Kuhlmann T, Rudel T. Deficiency of XIAP leads to sensitization for Chlamydophila pneumoniae pulmonary infection and dysregulation of innate immune response in mice. J Biol Chem. 2010 Jun 25;285(26):20291-302 doi: 10.1074/jbc.M109.096297 "PMID: 20427267; PMCID: PMC2888442"

    • Gurumurthy RK, Mäurer AP, Machuy N, Hess S, Pleissner KP, Schuchhardt J, Rudel T, Meyer TF. A loss-of-function screen reveals Ras- and Raf-independent MEK-ERK signaling during Chlamydia trachomatis infection. Sci Signal. 2010 Mar 16;3(113):ra21 doi: 10.1126/scisignal.2000651 PMID: 20234004

    • Kozjak-Pavlovic V, Ross K, Götz M, Goosmann C, Rudel T. A tag at the carboxy terminus prevents membrane integration of VDAC1 in mammalian mitochondria. J Mol Biol. 2010 Mar 19;397(1):219-32 doi: 10.1016/j.jmb.2010.01.047 PMID: 20117113

    • Niu H, Kozjak-Pavlovic V, Rudel T, Rikihisa Y. Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction. PLoS Pathog. 2010 Feb 19;6(2):e1000774 doi: 10.1371/journal.ppat.1000774 "PMID: 20174550; PMCID: PMC2824752"

    • Albrecht M, Sharma CM, Reinhardt R, Vogel J, Rudel T. Deep sequencing-based discovery of the Chlamydia trachomatis transcriptome. Nucleic Acids Res. 2010 Jan 38(3):868-77. doi: 10.1093/nar/gkp1032 "PMID: 19923228; PMCID: PMC2817459"

    • Asner GP, Rudel TK, Aide TM, Defries R, Emerson R. A contemporary assessment of change in humid tropical forests. Conserv Biol. 2009 Dec 23(6):1386-95. doi: 10.1111/j.1523-1739.2009.01333.x PMID: 20078639

    • Rudel TK, Schneider L, Uriarte M, Turner BL 2nd, DeFries R, Lawrence D, Geoghegan J, Hecht S, Ickowitz A, Lambin EF, Birkenholtz T, Baptista S, Grau R. Agricultural intensification and changes in cultivated areas, 1970-2005. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20675-80 doi: 10.1073/pnas.0812540106 "PMID: 19955435; PMCID: PMC2791618"

    • Rudel TK, Defries R, Asner GP, Laurance WF. Changing drivers of deforestation and new opportunities for conservation. Conserv Biol. 2009 Dec 23(6):1396-405. doi: 10.1111/j.1523-1739.2009.01332.x PMID: 20078640

    • Böhme L, Rudel T. Host cell death machinery as a target for bacterial pathogens. Microbes Infect. 2009 Nov 11(13):1063-70. doi: 10.1016/j.micinf.2009.08.014 PMID: 19733679

    • Kozjak-Pavlovic V, Dian-Lothrop EA, Meinecke M, Kepp O, Ross K, Rajalingam K, Harsman A, Hauf E, Brinkmann V, Günther D, Herrmann I, Hurwitz R, Rassow J, Wagner R, Rudel T. Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis. PLoS Pathog. 2009 Oct 5(10):e1000629. doi: 10.1371/journal.ppat.1000629 "PMID: 19851451; PMCID: PMC2759283"

    • Jung M, Mollenkopf HJ, Grimm C, Wagner I, Albrecht M, Waller T, Pilarsky C, Johannsen M, Stephan C, Lehrach H, Nietfeld W, Rudel T, Jung K, Kristiansen G. MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy. J Cell Mol Med. 2009 Sep 13(9B):3918-28. doi: 10.1111/j.1582-4934.2009.00705.x "PMID: 19228262; PMCID: PMC4516539"

    • Prakash H, Becker D, Böhme L, Albert L, Witzenrath M, Rosseau S, Meyer TF, Rudel T. cIAP-1 controls innate immunity to C. pneumoniae pulmonary infection. PLoS One. 2009 Aug 6;4(8):e6519 doi: 10.1371/journal.pone.0006519 "PMID: 19657383; PMCID: PMC2716518"

    • Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 2009 Aug 16(8):1093-107. doi: 10.1038/cdd.2009.44 "PMID: 19373242; PMCID: PMC2757140"

    • Rudel TK. How do people transform landscapes? A sociological perspective on suburban sprawl and tropical deforestation. AJS. 2009 Jul 115(1):129-54. PMID: 19852187

    • Ross K, Rudel T, Kozjak-Pavlovic V. TOM-independent complex formation of Bax and Bak in mammalian mitochondria during TNFalpha-induced apoptosis. Cell Death Differ. 2009 May 16(5):697-707. doi: 10.1038/cdd.2008.194 PMID: 19165229

    • Sharma M, Rudel T. Apoptosis resistance in Chlamydia-infected cells: a fate worse than death? FEMS Immunol Med Microbiol. 2009 Mar 55(2):154-61. doi: 10.1111/j.1574-695X.2008.00515.x PMID: 19281566

    • Kepp O, Gottschalk K, Churin Y, Rajalingam K, Brinkmann V, Machuy N, Kroemer G, Rudel T. Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection. PLoS Pathog. 2009 Mar 5(3):e1000348. doi: 10.1371/journal.ppat.1000348 "PMID: 19300516; PMCID: PMC2654407"

    • Rajalingam K, Sharma M, Lohmann C, Oswald M, Thieck O, Froelich CJ, Rudel T. Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells. PLoS One. 2008 Sep 1;3(9):e3102 doi: 10.1371/journal.pone.0003102 "PMID: 18769617; PMCID: PMC2518856"

    • Mantei A, Rutz S, Janke M, Kirchhoff D, Jung U, Patzel V, Vogel U, Rudel T, Andreou I, Weber M, Scheffold A. siRNA stabilization prolongs gene knockdown in primary T lymphocytes. Eur J Immunol. 2008 Sep 38(9):2616-25. doi: 10.1002/eji.200738075 PMID: 18792414

    • Wang JA, Meyer TF, Rudel T. Cytoskeleton and motor proteins are required for the transcytosis of Neisseria gonorrhoeae through polarized epithelial cells. Int J Med Microbiol. 2008 Apr 298(3-4):209-21. PMID: 17683982

    • Paland N, Böhme L, Gurumurthy RK, Mäurer A, Szczepek AJ, Rudel T. Reduced display of tumor necrosis factor receptor I at the host cell surface supports infection with Chlamydia trachomatis. J Biol Chem. 2008 Mar 7;283(10):6438-48 doi: 10.1074/jbc.M708422200 PMID: 18167350

    • Kozjak-Pavlovic V, Ross K, Rudel T. Import of bacterial pathogenicity factors into mitochondria. Curr Opin Microbiol. 2008 Feb 11(1):9-14. doi: 10.1016/j.mib.2007.12.004 PMID: 18280201

    • Schmidt F, Hustoft HK, Strozynski M, Dimmler C, Rudel T, Thiede B. Quantitative proteome analysis of cisplatin-induced apoptotic Jurkat T cells by stable isotope labeling with amino acids in cell culture, SDS-PAGE, and LC-MALDI-TOF/TOF MS. Electrophoresis. 2007 Dec 28(23):4359-68. PMID: 17987630

    • Rechner C, Kühlewein C, Müller A, Schild H, Rudel T. Host glycoprotein Gp96 and scavenger receptor SREC interact with PorB of disseminating Neisseria gonorrhoeae in an epithelial invasion pathway. Cell Host Microbe. 2007 Dec 13;2(6):393-403 PMID: 18078691

    • Satake A, Rudel TK. Modeling the forest transition: forest scarcity and ecosystem service hypotheses. Ecol Appl. 2007 Oct 17(7):2024-36. PMID: 17974339

    • Rajalingam K, Oswald M, Gottschalk K, Rudel T. Smac/DIABLO is required for effector caspase activation during apoptosis in human cells. Apoptosis. 2007 Aug 12(8):1503-10. PMID: 17440818

    • Machuy N, Campa F, Thieck O, Rudel T. c-Abl-binding protein interacts with p21-activated kinase 2 (PAK-2) to regulate PDGF-induced membrane ruffles. J Mol Biol. 2007 Jul 20;370(4):620-32 PMID: 17543336

    • Kozjak-Pavlovic V, Ross K, Benlasfer N, Kimmig S, Karlas A, Rudel T. Conserved roles of Sam50 and metaxins in VDAC biogenesis. EMBO Rep. 2007 Jun 8(6):576-82. "PMID: 17510655; PMCID: PMC2002532"

    • Kepp O, Rajalingam K, Kimmig S, Rudel T. Bak and Bax are non-redundant during infection- and DNA damage-induced apoptosis. EMBO J. 2007 Feb 7;26(3):825-34 "PMID: 17235284; PMCID: PMC1794390"

    • Rudel TK. Shrinking tropical forests, human agents of change, and conservation policy. Conserv Biol. 2006 Dec 20(6):1604-9. PMID: 17181795

    • Rajalingam K, Sharma M, Paland N, Hurwitz R, Thieck O, Oswald M, Machuy N, Rudel T. IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells. PLoS Pathog. 2006 Oct 2(10):e114. "PMID: 17069460; PMCID: PMC1626104"

    • Paland N, Rajalingam K, Machuy N, Szczepek A, Wehrl W, Rudel T. NF-kappaB and inhibitor of apoptosis proteins are required for apoptosis resistance of epithelial cells persistently infected with Chlamydophila pneumoniae. Cell Microbiol. 2006 Oct 8(10):1643-55. PMID: 16984419

    • Campa F, Machuy N, Klein A, Rudel T. A new interaction between Abi-1 and betaPIX involved in PDGF-activated actin cytoskeleton reorganisation. Cell Res. 2006 Sep 16(9):759-70. PMID: 16940963

    • Kühlewein C, Rechner C, Meyer TF, Rudel T. Low-phosphate-dependent invasion resembles a general way for Neisseria gonorrhoeae to enter host cells. Infect Immun. 2006 Jul 74(7):4266-73. "PMID: 16790801; PMCID: PMC1489691"

    • Kopp P, Lammers R, Aepfelbacher M, Woehlke G, Rudel T, Machuy N, Steffen W, Linder S. The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophages. Mol Biol Cell. 2006 Jun 17(6):2811-23. "PMID: 16554367; PMCID: PMC1474789"

    • Thiede B, Kretschmer A, Rudel T. Quantitative proteome analysis of CD95 (Fas/Apo-1)-induced apoptosis by stable isotope labeling with amino acids in cell culture, 2-DE and MALDI-MS. Proteomics. 2006 Jan 6(2):614-22. PMID: 16342138

    • Rajalingam K, Rudel T. Ras-Raf signaling needs prohibitin. Cell Cycle. 2005 Nov 4(11):1503-5. PMID: 16294014

    • Butzke D, Hurwitz R, Thiede B, Goedert S, Rudel T. Cloning and biochemical characterization of APIT, a new l-amino acid oxidase from Aplysia punctata. Toxicon. 2005 Oct 46(5):479-89. PMID: 16153453

    • Rajalingam K, Wunder C, Brinkmann V, Churin Y, Hekman M, Sievers C, Rapp UR, Rudel T. Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. Nat Cell Biol. 2005 Aug 7(8):837-43. PMID: 16041367

    • Thiede B, Treumann A, Kretschmer A, Söhlke J, Rudel T. Shotgun proteome analysis of protein cleavage in apoptotic cells. Proteomics. 2005 May 5(8):2123-30. PMID: 15846839

    • Fowler T, Bamberg S, Möller P, Klenk HD, Meyer TF, Becker S, Rudel T. Inhibition of Marburg virus protein expression and viral release by RNA interference. J Gen Virol. 2005 Apr 86(Pt 4):1181-8. PMID: 15784912

    • Machuy N, Thiede B, Rajalingam K, Dimmler C, Thieck O, Meyer TF, Rudel T. A global approach combining proteome analysis and phenotypic screening with RNA interference yields novel apoptosis regulators. Mol Cell Proteomics. 2005 Jan 4(1):44-55. PMID: 15567892

    • Thiede B, Rudel T. Proteome analysis of apoptotic cells. Mass Spectrom Rev. 2004 Sep Oct;23(5):333-49. PMID: 15264233

    • Butzke D, Machuy N, Thiede B, Hurwitz R, Goedert S, Rudel T. Hydrogen peroxide produced by Aplysia ink toxin kills tumor cells independent of apoptosis via peroxiredoxin I sensitive pathways. Cell Death Differ. 2004 Jun 11(6):608-17. PMID: 14765133

    • Machuy N, Rajalingam K, Rudel T. Requirement of caspase-mediated cleavage of c-Abl during stress-induced apoptosis. Cell Death Differ. 2004 Mar 11(3):290-300. PMID: 14657961

    • Walduck A, Rudel T, Meyer TF. Proteomic and gene profiling approaches to study host responses to bacterial infection. Curr Opin Microbiol. 2004 Feb 7(1):33-8. PMID: 15036137

    • Thiede B, Siejak F, Dimmler C, Rudel T. Prediction of translocation and cleavage of heterogeneous ribonuclear proteins and Rho guanine nucleotide dissociation inhibitor 2 during apoptosis by subcellular proteome analysis. Proteomics. 2002 Aug 2(8):996-1006. PMID: 12203895

    • Müller A, Rassow J, Grimm J, Machuy N, Meyer TF, Rudel T. VDAC and the bacterial porin PorB of Neisseria gonorrhoeae share mitochondrial import pathways. EMBO J. 2002 Apr 15;21(8):1916-29 "PMID: 11953311; PMCID: PMC125974"

    • Rajalingam K, Al-Younes H, Müller A, Meyer TF, Szczepek AJ, Rudel T. Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis. Infect Immun. 2001 Dec 69(12):7880-8. "PMID: 11705971; PMCID: PMC98885"

    • Popp A, Billker O, Rudel T. Signal transduction pathways induced by virulence factors of Neisseria gonorrhoeae. Int J Med Microbiol. 2001 Sep 291(4):307-14. PMID: 11680791

    • Müller A, Rudel T. Modification of host cell apoptosis by viral and bacterial pathogens. Int J Med Microbiol. 2001 Aug 291(3):197-207. PMID: 11554560

    • Thiede B, Dimmler C, Siejak F, Rudel T. Predominant identification of RNA-binding proteins in Fas-induced apoptosis by proteome analysis. J Biol Chem. 2001 Jul 13;276(28):26044-50 PMID: 11352910

    • Al-Younes HM, Rudel T, Brinkmann V, Szczepek AJ, Meyer TF. Low iron availability modulates the course of Chlamydia pneumoniae infection. Cell Microbiol. 2001 Jun 3(6):427-37. PMID: 11422085

    • Kamradt T, Rudel T, Selbach M, Schaible UE. A new home for infection research. Trends Microbiol. 2001 Feb 9(2):54-6. PMID: 11286190

    • Kamradt T, Rudel T, Englich S, Schaible UE. Institution profile: the Max-Planck-Institute for Infection biology and German Center for Rheumatological Research. Trends Microbiol. 2001 Feb 9(2):93-4. PMID: 11173249

    • Lorenzen DR, Günther D, Pandit J, Rudel T, Brandt E, Meyer TF. Neisseria gonorrhoeae porin modifies the oxidative burst of human professional phagocytes. Infect Immun. 2000 Nov 68(11):6215-22. "PMID: 11035728; PMCID: PMC97702"

    • Müller A, Günther D, Brinkmann V, Hurwitz R, Meyer TF, Rudel T. Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells. EMBO J. 2000 Oct 16;19(20):5332-43 "PMID: 11032801; PMCID: PMC314008"

    • Thiede B, Siejak F, Dimmler C, Jungblut PR, Rudel T. A two dimensional electrophoresis database of a human Jurkat T-cell line. Electrophoresis. 2000 Jul 21(13):2713-20. PMID: 10949150

    • Thiede B, Lamer S, Mattow J, Siejak F, Dimmler C, Rudel T, Jungblut PR. Analysis of missed cleavage sites, tryptophan oxidation and N-terminal pyroglutamylation after in-gel tryptic digestion. Rapid Commun Mass Spectrom. "2000;14(6):496-502 PMID: 10717661

    • Al-Younes HM, Rudel T, Meyer TF. Characterization and intracellular trafficking pattern of vacuoles containing Chlamydia pneumoniae in human epithelial cells. Cell Microbiol. 1999 Nov 1(3):237-47. PMID: 11207556

    • Rudel T. Caspase inhibitors in prevention of apoptosis. Herz. 1999 May 24(3):236-41. PMID: 10412648

    • Scheuerpflug I, Rudel T, Ryll R, Pandit J, Meyer TF. Roles of PilC and PilE proteins in pilus-mediated adherence of Neisseria gonorrhoeae and Neisseria meningitidis to human erythrocytes and endothelial and epithelial cells. Infect Immun. 1999 Feb 67(2):834-43. "PMID: 9916098; PMCID: PMC96394"

    • Naumann M, Rudel T, Meyer TF. Host cell interactions and signalling with Neisseria gonorrhoeae. Curr Opin Microbiol. 1999 Feb 2(1):62-70. PMID: 10047561

    • Bauer FJ, Rudel T, Stein M, Meyer TF. Mutagenesis of the Neisseria gonorrhoeae porin reduces invasion in epithelial cells and enhances phagocyte responsiveness. Mol Microbiol. 1999 Feb 31(3):903-13. PMID: 10048033

    • Müller A, Günther D, Düx F, Naumann M, Meyer TF, Rudel T. Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases. EMBO J. 1999 Jan 15;18(2):339-52 "PMID: 9889191; PMCID: PMC1171129"

    • Naumann M, Rudel T, Wieland B, Bartsch C, Meyer TF. Coordinate activation of activator protein 1 and inflammatory cytokines in response to Neisseria gonorrhoeae epithelial cell contact involves stress response kinases. J Exp Med 1998 Oct 5;188(7):1277-86 "PMID: 9763607; PMCID: PMC2212490"

    • Rudel T, Zenke FT, Chuang TH, Bokoch GM. p21-activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells. J Immunol. 1998 Jan 1;160(1):7-11 PMID: 9551947

    • Mellies J, Rudel T, Meyer TF. Transcriptional regulation of pilC2 in Neisseria gonorrhoeae: response to oxygen availability and evidence for growth-phase regulation in Escherichia coli. Mol Gen Genet. 1997 Jul 255(3):285-93. PMID: 9268019

    • Fussenegger M, Rudel T, Barten R, Ryll R, Meyer TF. Transformation competence and type-4 pilus biogenesis in Neisseria gonorrhoeae--a Gene. Gene. 1997 Jun 11;192(1):125-34. PMID: 9224882

    • Rudel T, Bokoch GM. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science. 1997 Jun 6;276(5318):1571-4 PMID: 9171063

    • Ryll RR, Rudel T, Scheuerpflug I, Barten R, Meyer TF. PilC of Neisseria meningitidis is involved in class II pilus formation and restores pilus assembly, natural transformation competence and adherence to epithelial cells in PilC-deficient gonococci. Mol Microbiol. 1997 Mar 23(5):879-92. PMID: 9076726

    • Rudel T, Schmid A, Benz R, Kolb HA, Lang F, Meyer TF. Modulation of Neisseria porin (PorB) by cytosolic ATP/GTP of target cells: parallels between pathogen accommodation and mitochondrial endosymbiosis. Cell. 1996 May 3;85(3):391-402 PMID: 8616894

    • Kupsch EM, Aubel D, Gibbs CP, Kahrs AF, Rudel T, Meyer TF. Construction of Hermes shuttle vectors: a versatile system useful for genetic complementation of transformable and non-transformable Neisseria mutants. Mol Gen Genet. 1996 Mar 20;250(5):558-69 PMID: 8676859

    • Rudel T, Boxberger HJ, Meyer TF. Pilus biogenesis and epithelial cell adherence of Neisseria gonorrhoeae pilC double knock-out mutants. Mol Microbiol. 1995 Sep 17(6):1057-71. PMID: 8594326

    • Rudel T, Facius D, Barten R, Scheuerpflug I, Nonnenmacher E, Meyer TF. Role of pili and the phase-variable PilC protein in natural competence for transformation of Neisseria gonorrhoeae. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7986-90 "PMID: 7644525; PMCID: PMC41271"

    • Rudel T, Scheurerpflug I, Meyer TF. Neisseria PilC protein identified as type-4 pilus tip-located adhesin. Nature. 1995 Jan 26;373(6512):357-9 PMID: 7830772

    • Rudel T, van Putten JP, Gibbs CP, Haas R, Meyer TF. Interaction of two variable proteins (PilE and PilC) required for pilus-mediated adherence of Neisseria gonorrhoeae to human epithelial cells. Mol Microbiol. 1992 Nov 6(22):3439-50. PMID: 1362447
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